Toll-like receptor 2 or toll-like receptor 4 deficiency does not modify lupus in MRLlpr mice.

Toll-like receptor 2 or toll-like receptor 4 deficiency does not modify lupus in MRLlpr mice.

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Systemic lupus erythematosus is an autoimmune disease with a high morbidity and nephritis is a common manifestation.Previous studies in murine lupus models have suggest a role for Toll-like receptor 2 and 4.We examined the role of these molecules in MRL lpr mice color touch 7/97 which is one of the most established and robust murine models.We compared disease parameters in Toll-like receptor 2 or Toll-like receptor 4 deficient mice with their littermate controls.We found no difference in the severity of glomerulonephritis as assessed by histology, serum creatinine and albuminuria when Toll-like receptor 2 or Toll-like receptor read more 4 deficient MRLlpr mice were compared with Toll-like receptor sufficient controls.

We also found similar levels of anti-dsDNA and anti-ssDNA antibodies.These results show that Toll-like receptor 2 and Toll-like receptor 4 do not play a significant role in MRLlpr mice, and therefore they may not be important in human lupus.