Toll-like receptor 2 or toll-like receptor 4 deficiency does not modify lupus in MRLlpr mice.
Systemic lupus erythematosus is an autoimmune disease with a high morbidity and nephritis is a common manifestation.Previous studies in murine lupus models have suggest a role for Toll-like receptor 2 and 4.We examined the role of these molecules in MRL lpr mice color touch 7/97 which is one of the most established and robust murine models.We compa